Effect of β-alanine on humoral immune response in low-dose allergy model

At the present time, efforts of many research groups around world are aimed at finding new factors triggering allergic sensitization process linked with IgE synthesis to harmless allergens. According recent data, production tissue cytokines is induced in cells by alarmins, thus, turn, eliciting pro-allergic immune response. Previously we have shown that β-alanine could be a potential alarmin capable stimulate cytokines. The aim this work was determine impact on humoral response low-dose allergy model. BALB/c mice were immunized recombinant Asp f 2 protein or commercial ovalbumin (OVA) withers 3 times week without supplementation. To mechanism effect, α-L-alanine, an isomer which not MrgD receptor ligand, and β-aminoisobutyrate β-alanine-like affinity compared. our stimulated specific IgG1 short-term course (7 immunizations) enhanced antibody after long-term (14 protocol case low-immunogenic 2. In high-immunogenic OVA protein, significant only upon affinity. Hence, accelerates protein. activation, because β-aminoisobutyrate, other ligand receptor, did similar effect seems also independent since common proteinogenic amino acid α-L-alanine production. its non-specific action, e.g., due ability induce oxidative stress through blocking taurine transporter, cellular metabolism.